Dr. Comings' Publications #201-300
201. Pekkala-Flagan, A. and Comings, D.E. Substitution of polybuffer far ampholytes in isoelectric focusing. Anal.
Biochem. 122: 295-297, l982.
202. Comings, D.E. Research prospectives in cytogenetics. Amer. J. Hum. Genet. 34: 157-162, 1982.
203. Peters, K.E., Okada, T.A. and Camings, D.E. Chinese hamster nuclear proteins. An electrophoretic analysis of
interphase, metaphase and nuclear matrix preparations. European J. Biochem. 129: 221-232, 1982.
204. Comings, D.E. Apple DIS and Autoprompt DIS. In Computers in Psychiatry/Psychology, M.D. Schwartz (ed.),
The Haworth Press, New York, l983.
205. Comings, D.E. and Comings, B.G. Tourette syndrome and attention deficit disorder with hyperactivity - Are
they genetically related? J. Amer. Acad. Child. Psychiatry 23: 138-l46, 1984.
206. Comings, D.E., Comings, B.G., Devor, E.J. and Cloninger, C.R. Detection of a major gene for Gilles de la
Tourette syndrome. Amer. J. Hum. Genet. 36: 586-600, l984.
207. Comings, D.E., Muhleman, D., and Sarinana, F. Individual quantitation of messenger RNA. (Abstract)
Amer. J. Hum. Genet. 36: 134A, 1984.
208. Comings, D.E. and Comings, B.G. Tourette syndrome. C1inical and psychological aspects of 250 cases. Amer. J.
Hum. Genet. 37: 435-450, 1985.
209. Comings, D.E. How do you find a gene when you don’t know what it does? (Abstract) Genetics Society of Canada
Bulletin 16: 52, 1985.
210. Comings, D.E. and Comings, B.G. Evidence for an X-linked modifier gene affecting the expression of Tourette
syndrome. (Abstract) American Society of Human Genetics Meeting, Salt Lake, 1985.
211. Comings, D.E. Genetics of Rett syndrome. The consequences of a disorder where every case is a new mutation.
Am. J. Med. Genet. 24: 383-388, 1986.
212. Comings, D.E. and Comings, B.G. Evidence for an X-linked modifier gene affecting the expression of Tourette
syndrome and its relevance to the increased frequency of speech, cognitive and behavioral disorders in males.
Proc. Nat. Acad. Sci. 83: 2551-2555, 1986.
213. Comings, D.E., Comings, B.G., Dietz, G., Muhleman, D., Okada, T.A., Sarinana, F., Simmer, R., Sparkes, R.,
Crist, M. and Stock, D. Linkage studies in Tourette syndrome. (Abstract) American Society of Human
Genetics Meeting, Philadelphia, 1986. Amer. J. Hum; Genet. 39:A151, 1986.
214. Comings, D.E., Comings, B.G., Dietz, G., Muhleman, D., Okada, T.A., Sarinana, F., Simmer, R., Stock, D.
Evidence the Tourette syndrome gene is at 18~22.1. (Abstract) Seventh International Congress of ffuman
Genetics, West Berlin, 1986.
215. Comings, D.E. and Comings, 8.G. Hereditary agoraphobia and - ~ oosessive-compulsive behavior in relatives of
patients with Tourette syndrome. Brit. J. Psychiatry 151: 195-199, l087.
216. Comings, D.E. and Comings, B.G. A controlled study of Tourette syndrome. I. Attention deficit disorder, learning
disorders, and school problems. Amer. J. Hum. Genet. 41: 701-741, 1987.
217. Comings, D.E. and Comings, B.G. A controlled study of Tourette syndrome. II. Conduct. Amer. J. Hum. Genet.
41: 742-760, 1987.
218. Comings, D.E. and Comings, B.G. A controlled study of ~ourette syndrome. III. Phobias and panic attacks. Amer.
J. Hum. Genet. 41: 761-781, 1987.
219. Comings, D.E. and Comings, B.G. A controlled study of Tourette syndrome. IV. Obsessions, compulsions, and
schizoid behaviors. Amer. J. Hum Genet. 41: 782-803, 1987.
220. Comings, B.G. and Comings, D.E. A controlled study of Tourette syndrome. V. Depression and mania. Amer. J.
Hum. Genet. 41: 804-321, 1987.
221. Comings, D.E. and Comings, B.G. A controlled studv of Tourette syndrome. VI. Earlv development, sleep
problems, allergies and handedness. Amer. J. Hum. Genet. 41: 322-838 1987.
222. Comings, D. E. A controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing
disinhibition of the limbic system. Am.J.Hum.Genet. 41: 839-866, 1987.
223. Comings, D. E. and Comings, B.G.,. Hereditary agoraphobia and obsessive-compulsive behaviour in relatives of
patients with Gilles de la Tourette's syndrome. Br.J.Psychiatry. 151: 195-199, 1987.
224. Comings, D. E. and Comings, B.G.,. Attention deficit disorder and Tourette syndrome. Letter to the Editor.
Arch.Gen.Psychiatry. 44: 1023-1025, 1987.
225. Comings, D. E. and Comings, B.G.,. A controlled study of Tourette syndrome-Revisited. A reply to the letter of
Pauls et al. Am.J.Hum.Genetics 43: 209-216, 1988.
226. Kovacs, B.W., Shahbahrami, B., Platt, L.D., and Comings, D.E. Molecular genetic prenatal determinations of twin
zygosity.
227. Comings, D. E. and Comings, B.G.,. The genetics of Tourette syndrome and its relationship to other psychiatric
disorders. Wenner Gren Int. Symposium Series. In Genetics of Neuropsychiatric Diseases, L. Wetterberg (ed.),
MacMillan Press, London, pp.179-189, 1989.
228. Comings, D.E. and Comings, B.G. Tourette syndrome, attention deficit disorder and learning disorders: Clinical,
genetic and biochemical interrelationships. (Abstract) ACLD Conference, 1989.
229. Comings, D. E. and Comings, B.G. Tourette's syndrome and attention deficit disorder. In Tourette's Syndrome and
Tic Disorders: Clinical Understanding and Treatment. John Wiley & Sons, New York, pp. 120-135, 1988.
230. Comings, D. E. The genetics of human behavior: Lessons for two societies. Presidential Address. American
Society of human Genetics Meeting, New Orleans. Am.J.Hum.Genet. 44: 452-460, 1989.
231. Comings, D. E., Comings, B. G., Dietz, G., and Muhleman, D. Localization of human tryptophan oxygenase to
4q31:Possible relevance to alcoholism, depression and Tourette syndrome. (Abstract) American Society of
Human Genetics, Am.J.Hum.Genet. 45: 35A, 1989.
232. Comings, D. E., Comings, B.G., and E. Knell. Hypothesis: Homozygosity in Tourette syndrome. Am.J.Med.Genet.
34: 413-421, 1989.
233. Comings, D. E., Comings, B. G., Muhleman, D., and Dietz, G.. Tourette syndrome, serotonin, tryptophan
oxygenase, type II alcoholism and depression. (Abstract) 1st World Congress Psychiatric Genetics, 1989.
234. Comings, D. E., Dietz, G., and Muhleman, D. Localization of human tryptophan oxygenase to 4q31.1-4qter.
(Abstract) Human Gene Mapping Conference. Cytogenetics Cell Genetics 51:979. 1989.
235. Donlon, T. A., Muhleman, D., Dietz, G., Comings, D. E., and Spak, D. K. Localization of human tryptophan
oxygenase to 4q31-4q32 by in situ hybridization. (Abstract) Human gene Mapping Conference. Cytogenetics
Cell Genetics 51, 992. 1989.
236. Knell, E. and Comings, D.E.,. Tourette syndrome (TS) and attention deficit disorder (ADD) in 337 first-degree
relatives of TS probands. (Abstract) American Society of Human Genetics Meeting. Am.J.Hum.Genet. 45:
50A, 1989.
237. Kovacs, B. W., Shahbahrami, B. and Comings, D. E. Studies of human germinal mutations by DNA
hybridization. Am.J.Obstet.Gynecol. 160: 798-804, 1989.
238. Comings, D. E. Blood serotonin and tryptophan in Tourette syndrome. Am.J.Med.Genet. 36: 418-430, 1990.
239. Comings, D. E. Tourette Syndrome and Human Behavior. Hope Press, Duarte, CA, 1990. (Book)
240. Comings, D. E. and Comings, B.G.,. A controlled family history study of Tourette syndrome. I. Attention deficit
hyperactivity disorder, learning disorders and dyslexia. J.Clin.Psychiat. 51: 275-280, 1990.
241. Comings, D. E. and Comings, B.G.,. A controlled family history study of Tourette syndrome. II. Alcoholism, drug
abuse and obesity. J.Clin.Psychiat. 51: 281-287, 1990.
242. Comings, D. E. and Comings, B.G.,. A controlled family history study of Tourette syndrome. III. Other Psychiatric
Disorders. J.Clin.Psychiat. 51: 288-291, 1990.
243. Comings, D. E., Comings, B. G., Tacket, T., and Li, S. The clonidine patch and behavioral problems. Letter to the Editor.
J.Am.Acad.Child.Adolesc.Psychiatry. 29: 667-668, 1990.
244. Comings, D. E., Himes, J.A., and Comings, B. G. An epidemiological study of Tourette syndrome in a single school district.
J.Clin.Psychiat. 51: 463-469, 1990.
245. Comings, D. E., Muhleman, D., Dietz, G. W.Donlon, T. Human tryptophan oxygenase localized to 4q31: Possible
implications for human behavioral disorders. Genomics 17: 20-25, 1990.
246. Comings, D. E., Muhleman, D., Dietz, G., Shahbahrami, B., Tast, D., and Kovacs, B. W. The dopamine D2 receptor gene is a
modifier of the expression of the Tourette syndrome (Gts) and ADHD gene. (Abstract) American Society of Human
Genetics Meeting, Cincinnati, 1990. Am.J.Hum.Genet. 46. 90, 1990.
247. Comings, D.E. Genetic studies of Tourette syndrome (Abstract). 13th CCNP Meeting, Banff, Canada, 1990.
248. Comings, D.E. and Comings, B.G. Autism evolving into Tourette Syndrome: A study of 14 cases. (Abstract). 1990.
249. Kovacs, B.W., Shahbahrami, B., and Comings, D.E. Quantitation and characterization of human germinal mutations at
hypervarialbe loci. Banbury Report 34:351-362, 1990.
250. Comings, D. E. The genetics of addictive behaviors. The role of childhood behavioral disorders. Addiction & Recovery
11: 13-16, 1991.
251. Comings, D. E. and Comings, B. G. Clinical and genetic relationships between autism-PDD and Tourette syndrome:
A study of 19 cases. Am.J.Med.Genet. 39: 180-191, 1991.
252. Comings, D. E. and Comings, B. G. Common genes for spectrum disorders: Implications for psychiatric genetics. (Abstract)
Second World Congress on psychiatric Genetics, England, 1991. Psychiat.Genet. 2: 5-6, 1991.
253. Comings, D. E., Comings, B. G., Muhleman, D. , Dietz, G., Shahbahrami, B., Tast, D. , Knell, E., Kocsis, P.,Baumgarten, R.,
Kovacs, B. W., Levy, D. L., Smith, M., Borison, R. L., Evans, D.D., Klein, D. N., MacMurray, J., Tosk, J., Sverd, J.,
Gysin, R. and Flanagan, S. D. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders.
J.Am.Med.Assn. 266: 1793-1800, 1991.
254. Comings, D.E. The future of behavioral genetics. (Abstract) Fourth SASHG Congress, South Africe, 1991.
255. Comings, D. E., Muhleman, D., Dietz, G., and Forest, J. Molecular genetic studies of the tryptophan oxygenase gene.
(Abstract) Second World Congress on Psychiatric Genetics, England, 1991. Psychiat.Genet. 2: 70-71, 1991.
256. Comings, D.E. and Comings, B.G. Common hereditary behavioral spectrum disorders. Implications for psyhiatric genetics.
(Abstract) 38th Annual Meeting of the Academy of Child and adolescent Psychiatry, San Francisco, 1991.
257. Comings, D.E., Comings, B.G., and Himes, J.A. A reply to Shaktman, D: Tourette’s syndrome in the developmentally
disabled. J. Clin. Psychiat. 252-279, 1991.
258. Coolbaugh, C.F., Comings, D.E. Lack of assocation of DRD2 gene and EEG measures of agression. (Abstract) Amer. J.
Psychol., 1991.
259. MacMurray, J., Comings, D., and Flanagan, S. Racial and ethnic differences in DRD2 allele and haplotype frequencies.
NIDA Technical Conference, “D2 Receptor Alleles in Substance Abuse: Have we Identified a Relevant Gene?” Baltimore,
Maryland, September 19-20, 1991.
260. MacMurray, J., Comings, D., and Flanagan, S. A1 Allele: A modifying gene in neuropsychiatric disorders. NIDA Technical
Conference, “D2 Receptor Alleles in Substance Abuse: Have We Identified a Relevant Gene?” Baltimore, Maryland,
September 19-20, 1991.
261. Comings, D. E., Muhleman, D., Dietz, G., The dopamine D2 receptor as a modifying gene in neuropsychiatric disorders.
(Abstraxt) Second World Congress on Psychiatric Genetics, England, 1991. Psychiat.Genet. 2: 69-70, 1991.
262. Palmer, C. G., Bader, P. , Slovak, M. L., Comings, D. E., and Pettenati, M. J. Partial Deletion of Chromosome 6p: Delineation
of the Syndrome. Am.J.Med.Genet. 39: 155-160, 1991.
263. Comings, D. E. Adult attention deficit hyperactivity disorder: Underdiagnosed, undertreated. Nutrition & Health Review,
p.4 -7, 1992.
264. Comings, D. E. The D2 dopamine receptor and Tourette's syndrome. J.Am.Med.Assn. 267: 652, 1992.
265. Comings, D. E. The role of a mutant dopamine receptor gene in ADHD: Implications for treatment and the relationship of
ADHD to Tourette Syndrome. CHADDER 6: 12-14, 1992.
266. Comings, D. E. and Comings, B. G. Alternative hypotheses on the inheritance of Tourette syndrome. Tourette Syndrome
Association Second International Scientific Symposium, Boston, 1991. Adv.Neurol. 58: 189-199, 1992.
267. Comings, D. E., MacMurray, J., Dietz, G., Muhleman, D., Knell, E., Flanagan, S. Gysin, R., Ask, M., and Johnson, J.
Dopamine D2 receptor (DRD2) as a major gene in obesity. (Abstract) American Society of Human Genetics, San
Francisco, 1992. Am.J.Hum.Genet. 51: A211, 1992.
268. Johnson, J. P., Comings, D.E., Flanagan, S.D., Nessan, D.G., Tosk, J.M., and Kelly, J.,. Genetic Influence on P300 Latency in
Substance Abusers, (Abstract). Clinical Neuropsychologist 6: 344, 1992.
269. Flanagan, S.D., MacMurray, j., Comings, D., Johnson, J., Lopatin, G., Gysin, R. Dopamine D2 receptor (DRD2) haplotype
status and genetic risk for alcoholism and polysubstance abuse. (Abstract) CINP XVIII Congress, Nice, 1992.
270. Comings, D.E. Serotonin, and alcoholism as a spectrum disorder. Symposium o n 5-HT in Alcoholism. (Abstract) Bristol,
England, 1992.
271. Kovacs, B. W., Shbahrami, B. Tast, D.E., Lee, S. H., and Comings, D.E. Quantitation and characterization of trinucleotide
repeat microsatellites in eukaryotic species. Am.J.Hum.Genet. 51: A366, 1992.
272. Flanagan, S.D., Noble, E. P., Blum, K., MacMurray, J., Comings, D., Ritchie, T., Sheridan, P.J., Lopatin, G., Gysin, R.
Evidence for a third physiologically distinct allele at the dopamine D2 receptor locus (DRD2). (Abstract) Amer.
Psychopathol. Assn., New York, 1992.
273. Comings, D.E., Ferry, l. Brandshaw-Robinson, S., Burchette, R., Dino, M., Chiu, C., Muhleman, D. Role of variants of the
dopamine D2 receptor (DRD2) gene as genetic risk factors in smoking. (Abstract) Tobacco-Related Disease Research
Program First TRDRP Scientific Conference, 1993.
274. Comings, D. E. Common genetic factors for drug and alcohol abuse: Tourette syndrome (Gts)/ADHD genes. Psychiat.Genet.
3: 176, 1993.
275. Comings, D. E. Genetic factors in human sexual behavior. Psychiat.Genet. 3: 181, 1993.
276. Comings, D. E. A genetic hypothesis for the secular increases in psychiatric disorders. Psychiat.Genet. 3: 176, 1993.
277. Comings, D. E. and Comings, B. G. Comorbid Behavioral Disorders. In Kurlan, R., ed. Handbook of Tourette's Syndrome
and Related Tic and Behavioral Disorders, 111-147. Marcel-Decker, Inc., New York, 1993.
278. Comings, D. E. and Comings, B. G. Sexual abuse or Tourette syndrome? Social Work 38: 347-350, 1993.
279. Comings, D. E. and Comings, B.G. SIDS and Tourette syndrome: Is there an etiologic relationship? J.Dev.Physical Disabil. 5:
265-279, 1993.
280. Comings, D. E. and Comings, B. G. Tourette syndrome: A hereditary neuropsychiatric spectrum disorder. Psychiat.Genet. 3:
117-118, 1993.
281. Comings, D. E. and Comings, B. G. Tourette syndrome: A neuropsychiatric spectrum disorder. (Abstract) Am.J.Hum.Genet.
53: 418, 1993.
282. Comings, D. E., Flanagan, S. D., Dietz, G., Muhleman, D., Knell, E., and Gysin, R. The dopamine D2 receptor (DRD2) as a
major gene in obesity and height. Biochem.Med.Metabolic Biol. 50: 176-185, 1993.
283. Comings, D. E., Muhleman, D., and Dietz, G.,. Within group association studies in oligogenetic spectrum disorders: Will they
lead us out of the wilderness of psychiatric genetics? Psychiat.Genet. 3: 187, 1993.
284. Comings, D. E., Muhleman, D., Dietz, G., Dino, M., Legro, R. and Gade. R. Association between Tourette's syndrome
and homozygosity at the dopamine-D3 receptor gene. Lancet 341: 706, 1993.
285. Comings, D. E., Muhleman, D., Dietz, G., M. Dino, R. Legro, and Gade, R.,. Tourette's syndrome and homozygosity for the
dopamine D3 receptor gene - reply. Lancet 341: 1483-1484, 1993.
286. Fahn, S., Bruun, R. D., Caine, E., Cohen, D.J., Comings, D.E., Como, P. G., Conneally, P.M., Gancher, S.T., Goetz, C.,
Golden, G.S., Jankovic, J., Kurlan, R., LeWitt, P., Pauls, D., Riddle, M.A., Shapiro, A.K., and Singer, H.S. Definitions
and classifications of tic disorders. Arch.Neurol. 50: 1013-1016, 1993.
287. Knell, E. and Comings, D.E.,. Tourette syndrome and attention deficit hyperactivity disorder: Evidence for a genetic
relationship. J.Clin.Psychiat. 54: 331-337, 1993.
288. Legro, R. S., Dietz, G., D. Comings, Lobo, R.A., Kovacs, B. D2 receptor gene haplotypes and decreased fecundability in
female Hispanics. (Abstract) Soc.Gynecologic Invest. Toronto, 1993.
289. Legro, R. S., G. W. Dietz, Comings, D.E., and B. W. Kovacs. D2 receptor gene haplotypes in female Hispanics are
significantly associated with gonadotropins and fecundity but not ovulation. (Abstract) The Endocrine Society, 1993.
290. Legro, R. S., Muhleman, D., D. Comings, R. A. Lobo, and B. Kovacs. D3 receptor polymorphisms associated with
oligo-ovulation among female Hispanics. (Abstract) Soc.Gynecologic Invest. Toronto, 1993.
291. MacMurray, J., Flanagan, S., and Comings, D. E. The role of DRD2 genetic variants in impulsive behaviors in samples of
normal individuals and substance abusers. (Abstract) 9th World Congress of Psychiatry, 1993.
292. Najfeld, V., Menniger, J., Muhleman, D., Comings, D.E., and Gupta, S.L. Localization of indoleamine 2,3-dioxygenase gene
to chromosome 8p12-p11 by fluorescent in situ hybridization. Cytogenetics Cell Genetics 64: 231-232, 1993.
293. Comings, D. E. Candidate genes and association studies in psychiatry. Letter to the editor. Am.J.Med.Gen.(Neuropsych.Genet.)
54: 324, 1994.
294. Comings, D. E. The dopamine D2 receptor gene (DRD2) and neuropsychiatric disorders. Therapeutic implications. CNS
Drugs 1: 1-5, 1994.
295. Comings, D. E. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives.
I. Drug abuse. Drug and Alcohol Dependence 35: 1-16, 1994.
296. Comings, D. E. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives.
II. Alcohol abuse. Drug and Alcohol Dependence 35: 17-24, 1994.
297. Comings, D. E. The role of genetic factors in human sexual behavior based on studies of Tourette syndrome and ADHD
probands and their relatives . Am.J.Med.Gen.(Neuropsych.Genet.) 54: 227-241, 1994.
298. Comings, D. E. Tourette syndrome: A behavioral spectrum disorder due to pleiotrophic expression of Gts genes. Movement
Disorders 9 (Suppl 1): 15, 1994.
299. Comings, D.E. and Comings, B.G. TS, learning, and speech problems. J.Am.Acad.Child.Adolesc.Psychiatry.
33: 429-430, 1994.
300. Comings, D.E., Gade, R., Muhleman, D. and Sverd, J. No association of a tyrosine hydroxylase gene tetranucleotide repeat
polymorphism in autism, Tourette syndrome or ADHD. Biol.Psychiatry 37: 484-486, 1995.